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Ravidasvir dihydrochloride

Chemical Structure : Ravidasvir dihydrochloride

CAS No.: 1303533-81-4

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Ravidasvir dihydrochloride (PPI-668, BI 238630)

Catalog No.: PC-61873Not For Human Use, Lab Use Only.

Ravidasvir (PPI-668, BI 238630) is a potent pan-genotypic HCV NS5A inhibitor with IC50 of 0.12/0.01/1.14 nM for HCV gt-1a/1b/3a in replicon luciferase assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Ravidasvir (PPI-668, BI 238630) is a potent pan-genotypic HCV NS5A inhibitor with IC50 of 0.12/0.01/1.14 nM for HCV gt-1a/1b/3a in replicon luciferase assay.
    Ravidasvir has been well tolerated and shown high sustained viral response rates as a key component in all-oral combination regimens in multiple human clinical trials.

    Physicochemical Properties

    M.Wt 835.83
    Formula C42H52Cl2N8O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Methyl N-[(2S)-1-{(2S)-2-[5-(6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}naphthalen-2-yl)-1H-benzimidazol-2-yl]pyrrolidin-1-yl}-3-methyl-1-oxobutan-2-yl]carbamate dihydrochloride

    References

    1. Zhong M, et al. Bioorg Med Chem Lett. 2016 Sep 15;26(18):4508-12.

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