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Chemical Structure : Razaxaban
Catalog No.: PC-60955Not For Human Use, Lab Use Only.
Razaxaban (DPC906, BMS561389) is a highly potent, selective, and orally bioavailable factor Xa (FXa) inhibitor with Ki of o.19 nM, >5,000-fold selectivity over a series of related serine proteases.
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Razaxaban (DPC906, BMS561389) is a highly potent, selective, and orally bioavailable factor Xa (FXa) inhibitor with Ki of o.19 nM, >5,000-fold selectivity over a series of related serine proteases.
Razaxaban (DPC906, BMS561389) inhibits thrombus formation in a dose-dependent manner with an ID50 of 1.6 µmol kg-1 h-1 in rabbit arterio-venous shunt thrombosis model.
| M.Wt | 528.472 | |
| Formula | C24H20F4N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Quan ML, et al. J Med Chem. 2005 Mar 24;48(6):1729-44.
2. Wong PC, et al. J Thromb Thrombolysis. 2007 Aug;24(1):43-51.
3. Zhang D, et al. Drug Metab Dispos. 2008 Feb;36(2):303-15.
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