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Razaxaban hydrochloride

Chemical Structure : Razaxaban hydrochloride

CAS No.: 405940-76-3

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Razaxaban hydrochloride (DPC 906;DPC906;BMS-561389;BMS561389)

Catalog No.: PC-60956Not For Human Use, Lab Use Only.

Razaxaban hydrochloride (DPC906, BMS561389) highly potent, selective, and orally bioavailable factor Xa (FXa) inhibitor with Ki of o.19 nM, >5,000-fold selectivity over a series of related serine proteases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Razaxaban hydrochloride (DPC906, BMS561389) highly potent, selective, and orally bioavailable factor Xa (FXa) inhibitor with Ki of o.19 nM, >5,000-fold selectivity over a series of related serine proteases.
    Razaxaban inhibits thrombus formation in a dose-dependent manner with an ID50 of 1.6 µmol kg-1 h-1 in rabbit arterio-venous shunt thrombosis model.

    Physicochemical Properties

    M.Wt 564.93
    Formula C24H21ClF4N8O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(3-amino-1,2-benzoxazol-5-yl)-N-[4-[2-[(dimethylamino)methyl]imidazol-1-yl]-2-fluorophenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide hydrochloride

    References

    1. Quan ML, et al. J Med Chem. 2005 Mar 24;48(6):1729-44.

    2. Wong PC, et al. J Thromb Thrombolysis. 2007 Aug;24(1):43-51.

    3. Zhang D, et al. Drug Metab Dispos. 2008 Feb;36(2):303-15.

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