Rebecsinib (17S-FD-895)

Chemical Structure : Rebecsinib

Catalog No.: PC-20015Not For Human Use, Lab Use Only.

Rebecsinib (17S-FD-895) is a selective small-molecule inhibitor of splicing-mediated ADAR1 activation, prevents leukemia stem cell generation.

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Biological Activity

Rebecsinib (17S-FD-895) is a selective small-molecule inhibitor of splicing-mediated ADAR1 activation, prevents leukemia stem cell generation.
Rebecsinib decreases RNA editing by inhibiting ADAR1 splicing into the most active editase, ADAR1p150.
Rebecsinib inhibits ADAR1p150-driven LSC self-renewal while sparing normal HSCs.
Rebecsinib impaired CD34+ KG-1a AML cell survival and increased RFP to GFP reporter expression in a dose-dependent manner (IC50=0.1 uM).
Rebecsinib inhibits ADAR1p150 mediated high-risk MF HPC and LSC survival.

Physicochemical Properties

M.Wt	566.73
Formula	C31H50O9
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3S,6S,7R,10S,E)-7,10-dihydroxy-2-((2E,4E,6R,7S)-7-hydroxy-7-((2R,3R)-3-((2R,3S)-3-methoxypentan-2-yl)oxiran-2-yl)-6-methylhepta-2,4-dien-2-yl)-3,7-dimethyl-12-oxooxacyclododec-4-en-6-yl acetate

References

1. Leslie A Crews, et al. Cell Stem Cell. 2023 Feb 14;S1934-5909(23)00008-5.

2. Butler MS. J Med Chem. 2013 Sep 12;56(17):6573-5.