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Chemical Structure : Rebecsinib
Catalog No.: PC-20015Not For Human Use, Lab Use Only.
Rebecsinib (17S-FD-895) is a selective small-molecule inhibitor of splicing-mediated ADAR1 activation, prevents leukemia stem cell generation.
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Rebecsinib (17S-FD-895) is a selective small-molecule inhibitor of splicing-mediated ADAR1 activation, prevents leukemia stem cell generation.
Rebecsinib decreases RNA editing by inhibiting ADAR1 splicing into the most active editase, ADAR1p150.
Rebecsinib inhibits ADAR1p150-driven LSC self-renewal while sparing normal HSCs.
Rebecsinib impaired CD34+ KG-1a AML cell survival and increased RFP to GFP reporter expression in a dose-dependent manner (IC50=0.1 uM).
Rebecsinib inhibits ADAR1p150 mediated high-risk MF HPC and LSC survival.
| M.Wt | 566.73 | |
| Formula | C31H50O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Leslie A Crews, et al. Cell Stem Cell. 2023 Feb 14;S1934-5909(23)00008-5.
2. Butler MS. J Med Chem. 2013 Sep 12;56(17):6573-5.
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