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Chemical Structure : Regdanvimab
CAS No.:
Catalog No.: PC-38893Not For Human Use, Lab Use Only.
Regdanvimab (Regkirona, CT-P59) is a recombinant human immunoglobulin G1 antibody targeted against SARS-CoV-2 sipke RBD, shows therapeutic effect against SARS-CoV-2 South African variants.
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Regdanvimab (Regkirona, CT-P59) is a recombinant human immunoglobulin G1 antibody targeted against SARS-CoV-2 sipke RBD, shows therapeutic effect against SARS-CoV-2 South African variants.
CT-P59 neutralized B.1.1.7 variant to a similar extent as to wild type virus.
CT-P59 showed reduced binding affinity against a RBD (receptor binding domain) triple mutant containing mutations defining B.1.351 (K417N/E484K/N501Y), also showed reduced potency against the SA variant in live virus and pseudovirus neutralization assay systems.
CT-P59 decrease B.1.351 viral load in the upper and lower respiratory tracts, comparable to that observed for the wild type virus.
Isotype: IgG1-lambda.
Anti-[human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein, receptor binding domain (RBD)], humanized and Homo sapiens monoclonal antibody.
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10 mM in DMSO |
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