Remlifanserin (ACP-204) | 5-HT2A inverse agonist

Chemical Structure : Remlifanserin

CAS No.: 2289704-13-6

Remlifanserin (ACP-204, ACP204)

Catalog No.: PC-25028Not For Human Use, Lab Use Only.

Remlifanserin (ACP-204, ACP204) is a potent, selective 5-HT2A serotonin receptor inverse agonist with Ki of 0.14 nM, acts as an antagonist/inverse agonist and has potencies of 0.3-0.5 nM.

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5 mg	$158	In stock
10 mg	$248	In stock
25 mg	$428	In stock
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Biological Activity

Remlifanserin (ACP-204, ACP204) is a potent, selective 5-HT2A serotonin receptor inverse agonist with Ki of 0.14 nM, acts as an antagonist/inverse agonist and has potencies of 0.3-0.5 nM.

ACP-204 did not have any appreciable functional activity (off-target effects) against 19 other monoamine targets at 5 uM.

ACP-204 reduced the potential to impact ion channels important in cardiovascular function compared with pimavanserin.

ACP-204 potently suppressed DOI-induced head twitches in mice and rats with minimum effective SC doses of 0.1 and 0.3 mg/kg, respectively.

ACP-204 achieved nearly complete suppression in mice and rats at SC doses of 0.3 and 1 mg/kg, respectively, and at an oral dose of 3 mg/kg in rats.

ACP-204 suppressed MK-801–induced locomotor activity in mice with a minimum effective dose of 0.1 mg/kg.

Physicochemical Properties

M.Wt	429.51
Formula	C24H29F2N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-cyclopropoxybenzyl)-1-(2,4-difluorobenzyl)-1-(1-methylpiperidin-4-yl)urea

References

1. Patent WO2019040107 A1.

Remlifanserin (ACP-204, ACP204)

Biological Activity

Physicochemical Properties

References

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