Remodelin is a potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules.
Remodelin significantly reduces the prevalence of misshapen nuclei in HGPS cells, prevents FTI-induced nuclear shape defects in normal fibroblasts and U2OS cells.
Remodelin does not affect Golgi apparatus integrity or tubulin polymer assembly, and does not cause cells to accumulate in mitosis.
