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Remodelin

Chemical Structure : Remodelin

CAS No.: 949912-58-7

Remodelin (NAT10 inhibitor)

Catalog No.: PC-45051Not For Human Use, Lab Use Only.

Remodelin is a potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules.

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Biological Activity

Remodelin is a potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules.
Remodelin significantly reduces the prevalence of misshapen nuclei in HGPS cells, prevents FTI-induced nuclear shape defects in normal fibroblasts and U2OS cells.
Remodelin does not affect Golgi apparatus integrity or tubulin polymer assembly, and does not cause cells to accumulate in mitosis.

Physicochemical Properties

M.Wt 282.3635
Formula C15H14N4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-

References

1. Larrieu D, et al. Science. 2014 May 2;344(6183):527-32.

2. Mathieu J, et al. Cell Stem Cell. 2016 Jul 7;19(1):3-4.

3. Cobb AM, et al. Aging Cell. 2016 Jul 27. doi: 10.1111/acel.12506.

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