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Chemical Structure : Remodelin
CAS No.: 949912-58-7
Catalog No.: PC-45051Not For Human Use, Lab Use Only.
Remodelin is a potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $228 | In stock | |
| 100 mg | $558 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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Remodelin is a potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules.
Remodelin significantly reduces the prevalence of misshapen nuclei in HGPS cells, prevents FTI-induced nuclear shape defects in normal fibroblasts and U2OS cells.
Remodelin does not affect Golgi apparatus integrity or tubulin polymer assembly, and does not cause cells to accumulate in mitosis.
| M.Wt | 282.3635 | |
| Formula | C15H14N4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]- |
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1. Larrieu D, et al. Science. 2014 May 2;344(6183):527-32.
2. Mathieu J, et al. Cell Stem Cell. 2016 Jul 7;19(1):3-4.
3. Cobb AM, et al. Aging Cell. 2016 Jul 27. doi: 10.1111/acel.12506.
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