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Chemical Structure : Remodelin hydrobromide
CAS No.: 1622921-15-6
Catalog No.: PC-45052Not For Human Use, Lab Use Only.
Remodelin hydrobromide is a potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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Remodelin hydrobromide is a potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules.
Remodelin significantly reduces the prevalence of misshapen nuclei in HGPS cells, prevents FTI-induced nuclear shape defects in normal fibroblasts and U2OS cells.
Remodelin does not affect Golgi apparatus integrity or tubulin polymer assembly, and does not cause cells to accumulate in mitosis.
| M.Wt | 363.2754 | |
| Formula | C15H15BrN4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 44 mg/mL |
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| Chemical Name/SMILES |
Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-, hydrobromide (1:1) |
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1. Larrieu D, et al. Science. 2014 May 2;344(6183):527-32.
2. Mathieu J, et al. Cell Stem Cell. 2016 Jul 7;19(1):3-4.
3. Cobb AM, et al. Aging Cell. 2016 Jul 27. doi: 10.1111/acel.12506.
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