Rencofilstat (CRV431) | Cyclophilin inhibitor

Chemical Structure : Rencofilstat

Rencofilstat (CRV431, CRV-431)

Catalog No.: PC-38419Not For Human Use, Lab Use Only.

Rencofilstat (CRV431) is a non-immunosuppressive analogue of cyclosporine A and pan-cyclophilin inhibitor, potently inhibits cyclophilin isoforms A, B, D, and G with IC50 of 1-7 nM.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Rencofilstat (CRV431) is a non-immunosuppressive analogue of cyclosporine A and pan-cyclophilin inhibitor, potently inhibits cyclophilin isoforms A, B, D, and G with IC50 of 1-7 nM.
Rencofilstat (CRV431) is more than 13 times more potent than the parent compound, cyclosporine A (CsA).
Rencofilstat (CRV431) inhibits liver HBV DNA and HBsAg, reduces liver HBV DNA levels and moderately decreased serum HBsAg levels in HBV transgenic mouse model.
Rencofilstat (CRV431) shows potential as a drug candidate for chronic liver diseases.

Physicochemical Properties

M.Wt	1303.784
Formula	C67H122N12O13
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((7R,8R)-8-((2S,5S,8R,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,8,10,16,20,23,25,28,31-decamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl)-8-hydroxy-7-methyloctyl)acetamide

References

1. Gallay P, et al. PLoS One. 2019 Jun 10;14(6):e0217433.

2. Kuo J, et al. J Pharmacol Exp Ther. 2019 Nov;371(2):231-241.

3. Trepanier DJ, et al. J Pharm Pharm Sci. 2018;21(1s):335s-348s.

Rencofilstat (CRV431, CRV-431)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.