Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Resminostat
CAS No.: 864814-88-0
Catalog No.: PC-44034Not For Human Use, Lab Use Only.
A potent inhibitor of HDAC1/3/6 with IC50s of 43-72 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $424 | In stock | |
| 100 mg | $680 | In stock |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent inhibitor of HDAC1/3/6 with IC50s of 43-72 nM; induces hyperacetylation of histone H4 and apoptosis in MM cell lines (IC50=2.5-3 uM); decreases levels of cyclin D1, cdc25a, Cdk4 and pRb as well as upregulation of p21; downregulates phosphorylation of 4E-BP1 and p70S6k.
Liver Cancer
Phase 2 Clinical
| M.Wt | 349.4048 | |
| Formula | C16H19N3O4S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-Propenamide, 3-[1-[[4-[(dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-, (2E)- |
|
1. Mandl-Weber S, et al. Br J Haematol. 2010 May;149(4):518-28.
2. Fu M, et al. Biochem Biophys Res Commun. 2016 Sep 2;477(4):527-33.
3. Enzenhofer E, et al. Head Neck. 2017 May;39(5):900-907.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
