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Chemical Structure : Resminostat hydrochloride
CAS No.: 1187075-34-8
Catalog No.: PC-44035Not For Human Use, Lab Use Only.
Resminostat (4SC-201, RAS2410) hydrochloride is a potent inhibitor of HDAC1/3/6 with IC50s of 43-72 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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Resminostat (4SC-201, RAS2410) hydrochloride is a potent inhibitor of HDAC1/3/6 with IC50s of 43-72 nM.
Resminostat induces hyperacetylation of histone H4 and apoptosis in MM cell lines (IC50=2.5-3 uM).
Resminostat decreases levels of cyclin D1, cdc25a, Cdk4 and pRb as well as upregulation of p21.
Resminostat downregulates phosphorylation of 4E-BP1 and p70S6k.
| M.Wt | 385.8657 | |
| Formula | C16H20ClN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 50 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, 3-[1-[[4-[(dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-, hydrochloride (1:1), (2E)- |
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1. Mandl-Weber S, et al. Br J Haematol. 2010 May;149(4):518-28.
2. Fu M, et al. Biochem Biophys Res Commun. 2016 Sep 2;477(4):527-33.
3. Enzenhofer E, et al. Head Neck. 2017 May;39(5):900-907.
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