Catalog No.: PC-21069Not For Human Use, Lab Use Only.
Retatrutide (LY3437943) is a potent, triple agonist peptide of glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) with EC50 of 5.79 nM, 0.064 nM and 0.775 nM in cAMP assays.
Retatrutide (LY3437943) is a potent, triple agonist peptide of glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) with EC50 of 5.79 nM, 0.064 nM and 0.775 nM in cAMP assays.
Retatrutide (LY3437943) is a full agonist at the GCGR, GIPR, and GLP-1R in the functional assays.
Retatrutide (LY3437943) also is a potent agonist at the mouse GCGR, GIPR, and GLP-1R in receptor binding affinity and functional potency assays in vitro.
Retatrutide (LY3437943) promotes body weight loss in C57/Bl6 diet-induced obese (DIO) mice with ED50 of 4.73 nmol/kg.
Retatrutide (LY3437943) increases energy expenditure through glucagon receptor engagement in obese mice.
Retatrutide (LY3437943) causes greater body weight loss in obese mice than tirzepatide (Cat# PC-72629), increases energy expenditure through glucagon receptor activation.
