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Chemical Structure : Retatrutide
CAS No.: 2381089-83-2
Catalog No.: PC-21069Not For Human Use, Lab Use Only.
Retatrutide (LY3437943) is a potent, triple agonist peptide of glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) with EC50 of 5.79 nM, 0.064 nM and 0.775 nM in cAMP assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $258 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Retatrutide (LY3437943) is a potent, triple agonist peptide of glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R) with EC50 of 5.79 nM, 0.064 nM and 0.775 nM in cAMP assays.
Retatrutide (LY3437943) is a full agonist at the GCGR, GIPR, and GLP-1R in the functional assays.
Retatrutide (LY3437943) also is a potent agonist at the mouse GCGR, GIPR, and GLP-1R in receptor binding affinity and functional potency assays in vitro.
Retatrutide (LY3437943) promotes body weight loss in C57/Bl6 diet-induced obese (DIO) mice with ED50 of 4.73 nmol/kg.
Retatrutide (LY3437943) increases energy expenditure through glucagon receptor engagement in obese mice.
Retatrutide (LY3437943) causes greater body weight loss in obese mice than tirzepatide (Cat# PC-72629), increases energy expenditure through glucagon receptor activation.
| M.Wt | 4731.33 | |
| Formula | C221H342N46O68 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
L-Serinamide, L-tyrosyl-2-methylalanyl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-isoleucyl-2-methyl-L-leucyl-L-leucyl-L-alpha-aspartyl-L-lysyl-N6-[N-(19-carboxy-1-oxononadecyl)-L-gamma-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-alanyl-L-glutaminyl-2-methylalanyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-alpha-glutamyl-L-tyrosyl-L-leucyl-L-leucyl-L-alpha-glutamylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl |
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1. Coskun T, et al. Cell Metab. 2022 Sep 6;34(9):1234-1247.e9.
2. Rosenstock J, et al. Lancet. 2023 Aug 12;402(10401):529-544.
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