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Revaprazan hydrochloride

Chemical Structure : Revaprazan hydrochloride

CAS No.: 178307-42-1

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Revaprazan hydrochloride (SB-641257;YH-1885)

Catalog No.: PC-62891Not For Human Use, Lab Use Only.

Revaprazan (SB-641257.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Revaprazan (SB-641257;YH-1885) potent potassium-competitive acid blocker (P-CAB) that inhibits H+,K+-ATPase in a reversible and K+-competitive manner; reduces gastric acid secretion, also exerts anti-inflammatory action against Helicobacter pylori-induced COX-2 expression by inactivating Akt signaling.

Ulcer

Approved

Physicochemical Properties

M.Wt 398.91
Formula C22H24ClFN4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-fluorophenyl)-4,5-dimethyl-6-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)pyrimidin-2-amine hydrochloride

References

1. Li H, et al. Drug Metab Dispos. 2001 Jan;29(1):54-9.

2. Lee JS, et al. J Clin Biochem Nutr. 2012 Sep;51(2):77-83.

3. Inatomi N, et al. Pharmacol Ther. 2016 Dec;168:12-22.

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