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Revefenacin

Chemical Structure : Revefenacin

CAS No.: 864750-70-9

Revefenacin (TD 4208;TD4208;GSK 1160724)

Catalog No.: PC-61043Not For Human Use, Lab Use Only.

Revefenacin (TD4208, GSK 1160724) is a novel potent, long-acting, lung-selective inhaled muscarinic antagonist that has high affinity at M3 receptor, demonstrates in vitro kinetic selectivity for M3 over M2 and no meaningful off-target activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Revefenacin (TD4208, GSK 1160724) is a novel potent, long-acting, lung-selective inhaled muscarinic antagonist that has high affinity at M3 receptor, demonstrates in vitro kinetic selectivity for M3 over M2 and no meaningful off-target activity.
Revefenacin produces sustained inhibition of acetylcholine-induced bronchoconstriction for up to 24 hours along with tiotropium and glycopyrronium.
Revefenacin has the potential to be a long-acting bronchodilator for once-daily treatment of respiratory diseases.

Physicochemical Properties

M.Wt 597.76
Formula C35H43N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester

References

1. Pulido-Rios MT, et al. J Pharmacol Exp Ther. 2013 Aug;346(2):241-50.

2. Mastrodicasa MA, et al. Expert Opin Investig Drugs. 2017 Feb;26(2):161-174

3. Quinn D, et al. Pulm Pharmacol Ther. 2017 Oct 4. pii: S1094-5539(17)30119-0.

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