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Chemical Structure : Revefenacin
CAS No.: 864750-70-9
Catalog No.: PC-61043Not For Human Use, Lab Use Only.
Revefenacin (TD4208, GSK 1160724) is a novel potent, long-acting, lung-selective inhaled muscarinic antagonist that has high affinity at M3 receptor, demonstrates in vitro kinetic selectivity for M3 over M2 and no meaningful off-target activity.
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|---|---|---|---|
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| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
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Revefenacin (TD4208, GSK 1160724) is a novel potent, long-acting, lung-selective inhaled muscarinic antagonist that has high affinity at M3 receptor, demonstrates in vitro kinetic selectivity for M3 over M2 and no meaningful off-target activity.
Revefenacin produces sustained inhibition of acetylcholine-induced bronchoconstriction for up to 24 hours along with tiotropium and glycopyrronium.
Revefenacin has the potential to be a long-acting bronchodilator for once-daily treatment of respiratory diseases.
| M.Wt | 597.76 | |
| Formula | C35H43N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester |
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1. Pulido-Rios MT, et al. J Pharmacol Exp Ther. 2013 Aug;346(2):241-50.
2. Mastrodicasa MA, et al. Expert Opin Investig Drugs. 2017 Feb;26(2):161-174
3. Quinn D, et al. Pulm Pharmacol Ther. 2017 Oct 4. pii: S1094-5539(17)30119-0.
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