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Chemical Structure : Rheb inhibitor NR1
CAS No.: 2216763-38-9
Catalog No.: PC-62515Not For Human Use, Lab Use Only.
Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $288 | In stock | |
| 25 mg | $458 | In stock | |
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| 100 mg | Get quote |
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Rheb inhibitor NR1 is a small molecule that binds Rheb in the switch II domain (IC50=2.1 uM, Kd=1.5 uM) and selectively blocks mTORC1 signaling, potently inhibits mTORC1 driven phosphorylation of S6K1 but does not inhibit phosphorylation of AKT or ERK.
In contrast to rapamycin, NR1 does not cause inhibition of mTORC2 upon prolonged treatment, potently and selectively inhibits mTORC1 in mouse kidney and muscle in vivo.
| M.Wt | 578.302 | |
| Formula | C25H19BrCl2N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-bromo-6-((3,4-dichlorophenyl)thio)-1-(4-(dimethylcarbamoyl)benzyl)-1H-indole-2-carboxylic acid |
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1. Mahoney SJ, et al. Nat Commun. 2018 Feb 7;9(1):548.
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