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Ribavirin

Chemical Structure : Ribavirin

CAS No.: 36791-04-5

Ribavirin (Tribavirin, Ribasphere)

Catalog No.: PC-28223Not For Human Use, Lab Use Only.

Ribavirin (Tribavirin, Ribasphere) is a synthetic guanosine analog with broad-spectrum of antiviral activity including HCV, HIV and RSV, inhibits the replication of RNA viruses such as flavi- and paramyxoviruses via inhibition of inosine monophosphate dehydrogenase enzyme (IMPDH), also inhibits viral RNA capping and the induces an error catastrophe.

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Biological Activity

Ribavirin (Tribavirin, Ribasphere) is a synthetic guanosine analog with broad-spectrum of antiviral activity including HCV, HIV and RSV, inhibits the replication of RNA viruses such as flavi- and paramyxoviruses via inhibition of inosine monophosphate dehydrogenase enzyme (IMPDH), also inhibits viral RNA capping and the induces an error catastrophe.

Physicochemical Properties

M.Wt 244.20
Formula C8H12N4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carboxamide

References

1. Ogbomo H, et al. Biochem Pharmacol. 2010 Jan 15;79(2):188-97.

2. Saito Y, et al. Bioorg Med Chem. 2003 Aug 15;11(17):3633-9.

3. Scheidel LM, et al. Virology. 1987 May;158(1):1-7.

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