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Rifapentine

Chemical Structure : Rifapentine

CAS No.: 61379-65-5

Rifapentine

Catalog No.: PC-28806Not For Human Use, Lab Use Only.

Rifapentine is a semisynthetic derivative antibiotic of rifampicin, inhibits DNA-dependent RNA polymerase in susceptible strains of M. tuberculosis, leading to a suppression of RNA synthesis and cell death, shwos potent antibacterial activity against TB and other mycobacterial species.

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Biological Activity

Rifapentine is a semisynthetic derivative antibiotic of rifampicin, inhibits DNA-dependent RNA polymerase in susceptible strains of M. tuberculosis, leading to a suppression of RNA synthesis and cell death, shwos potent antibacterial activity against TB and other mycobacterial species.

Physicochemical Properties

M.Wt 877.03
Formula C47H64N4O12
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-3-(((4-Cyclopentyl-1-piperazinyl)imino)methyl)-21-(Acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione

References

1. Artsimovitch I, et al. Cell. 2005 Aug 12;122(3):351-63.

2. Wichelhaus TA, et al. Antimicrob Agents Chemother. 1999 Nov;43(11):2813-6.

3. Williams DL, et al. Antimicrob Agents Chemother. 1998 Jul;42(7):1853-7.

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