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Rilpivirine

Chemical Structure : Rilpivirine

CAS No.: 500287-72-9

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Rilpivirine (R 278474;TMC 278;R-278474;R278474;TMC278;TMC-278)

Catalog No.: PC-42661Not For Human Use, Lab Use Only.

Rilpivirine (R278474, TMC278) is a highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse trK7912:M7912anscriptase with IC50 of 0.4 nM for WT HIV-1 in cell-based assay.

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100 mg $298 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Rilpivirine (R278474, TMC278) is a highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse trK7912:M7912anscriptase with IC50 of 0.4 nM for WT HIV-1 in cell-based assay.
Rilpivirine (R278474, TMC278) shows activity against a panel of single and double HIV-1 site-directed mutant (IC50=0.3-2 nM); orally active.

Physicochemical Properties

M.Wt 366.4185
Formula C22H18N6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzonitrile, 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-

References

1. Janssen PA, et al. J Med Chem. 2005 Mar 24;48(6):1901-9.

2. Das K, et al. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1466-71.

3. Azijn H, et al. Antimicrob Agents Chemother. 2010 Feb;54(2):718-27.

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