Catalog No.: PC-21792Not For Human Use, Lab Use Only.
Rimegepant (BMS-927711) is a potent, selective and orally active calcitonin gene-related peptide (CGRP) antagonist with Ki of 0.027 nM, inhibits CGRP-stimulated cAMP production in SK-N-MC cells with EC50 of 0.14 nM.
Rimegepant (BMS-927711) is a potent, selective and orally active calcitonin gene-related peptide (CGRP) antagonist with Ki of 0.027 nM, inhibits CGRP-stimulated cAMP production in SK-N-MC cells with EC50 of 0.14 nM. Rimegepant (BMS-927711) shows no significant potential for off-target liabilities in a panel of 45 receptor and ion channel binding and enzyme activity assays. Rimegepant (BMS-927711) inhibits hαCGRP-induced increases in marmoset facial blood flow upon subcutaneous (SC) dosing. Rimegepant (BMS-927711) shows good metabolic stability, acceptable CYP inhibition profile, good animal PK, and a favorable predictive toxicological profile.
