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Chemical Structure : Riociguat
CAS No.: 625115-55-1
Catalog No.: PC-20917Not For Human Use, Lab Use Only.
Riociguat (BAY 63-2521) is a potent, orally active stimulator of soluble guanylate cyclase (sGC) with MEC of 0.03 uM for achieve threefold stimulation of cGMP formation in recombinant sGC-overexpressing cell line.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 1 g | Get quote |
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Riociguat (BAY 63-2521) is a potent, orally active stimulator of soluble guanylate cyclase (sGC) with MEC of 0.03 uM for achieve threefold stimulation of cGMP formation in recombinant sGC-overexpressing cell line.
Riociguat (BAY 63-2521) inhibits the contraction of rabbit aorta with IC50 of 120 nM.
Riociguat (BAY 63-2521) exerts strong effects on pulmonary hemodynamics and exercise capacity in patients with pulmonary hypertension (PH).
| M.Wt | 422.42 | |
| Formula | C20H19FN8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate |
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1. Mittendorf J, et al. ChemMedChem. 2009 May;4(5):853-65.
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