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Chemical Structure : Rislenemdaz
CAS No.: 808732-98-1
Catalog No.: PC-42691Not For Human Use, Lab Use Only.
Rislenemdaz (MK-0657, CERC-301) is a potent, orally bioavailable brain‐penetrant, NR2B-selective NMDA receptor (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM respectively, with no off-target activity.
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|---|---|---|---|
| 5 mg | $388 | In stock | |
| 10 mg | $588 | In stock | |
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Rislenemdaz (MK-0657, CERC-301) is a potent, orally bioavailable brain‐penetrant, NR2B-selective NMDA receptor (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM respectively, with no off-target activity.
Rislenemdaz (MK-0657, CERC-301) inhibits calcium influx into agonist‐stimulated NMDA‐GluN1a/GluN2B L(tk‐) cells with IC50 of 3.6 nM, with no effect on GluN2A up to 30 uM.
Rislenemdaz (MK-0657, CERC-301) significantly decreases immobility frequency and increases swimming behavior in acute depression models.
| M.Wt | 358.417 | |
| Formula | C19H23FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(4-Methylphenyl)methyl (3S,4R)-3-fluoro-4-[(2-pyrimidinylamino)methyl]-1-piperidinecarboxylate |
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1. Addy C, et al. J Clin Pharmacol. 2009 Jul;49(7):856-64.
2. Ibrahim L, et al. J Clin Psychopharmacol. 2012 Aug;32(4):551-7.
3. Garner R, et al. Pharmacol Res Perspect. 2015 Dec 23;3(6):e00198.
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