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Risuteganib

Chemical Structure : Risuteganib

CAS No.: 1307293-62-4

Risuteganib (ALG1001, ALG-1001)

Catalog No.: PC-35165Not For Human Use, Lab Use Only.

Risuteganib (ALG-1001) is a first-in-class, RGD class oligopeptide that inhibits integrin receptors (αvβ3, αvβ5, and α5β1) associated with angiogenesis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Risuteganib (ALG-1001) is a first-in-class, RGD class oligopeptide that inhibits integrin receptors (αvβ3, αvβ5, and α5β1) associated with angiogenesis.
ALG1001 inhibits an integrin-mediated pathway of the vitreoretinal interface, connecting the posterior aspect of the vitreous with the internal limiting membrane of the retina.
In blocking this pathway, ALG-1001 helps to achieve vitreous breakdown and separation from the retina.

Physicochemical Properties

M.Wt 637.666
Formula C22H39N9O11S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

L-Proline, glycyl-L-arginylglycyl-3-sulfo-L-alanyl-L-threonyl-

References

1. Yang P, et al. Invest Ophthalmol Vis Sci. 2020 Aug 3;61(10):35.
2. Schneider K, et al. Exp Eye Res. 2021 Feb;203:108287.

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