Ro 25-1553 | VIPR2 agonist | Probechem Biochemicals

Chemical Structure : Ro 25-1553

Ro 25-1553 (Ro25-1553)

Catalog No.: PC-20660Not For Human Use, Lab Use Only.

Ro 25-1553 is a potent, selective VIPR2 agonist and a cyclic peptide analog of vasoactive intestinal peptide (VIP), displaces the radioligand 125I-VIP from rat forebrain membranes with IC50 of 4.98 nM.

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Biological Activity

Ro 25-1553 is a potent, selective VIPR2 agonist and a cyclic peptide analog of vasoactive intestinal peptide (VIP), displaces the radioligand 125I-VIP from rat forebrain membranes with IC50 of 4.98 nM.
Ro 25-1553 is 24 to 89 times more potent than VIP as a relaxant of guinea pig trachea.
Ro 25-1553 is inactive in a battery of 40 other binding assays (e.g., muscarinic, histamine, LTs, Ca++, TxA2, endothelin, alpha and beta adrenergic, platelet-activating factor, neurokinins, etc.) at 10 uM.
Ro 25-1553 exhibited potent smooth muscle relaxant activity in vitro.
Ro 25-1553 inhibited pulmonary responses evoked by histamine, leukotriene D4, platelet-activating factor and acetylcholine after in vivo intratracheal administration.

Physicochemical Properties

M.Wt	3562.05
Formula	C160H258N46O46
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Threoninamide, N-acetyl-L-histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-α-glutamyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-norleucyl-L-alanyl-L-alanyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-α-aspartyl-L-leucyl-L-lysyl-L-lysylglycylglycyl-, (25→21)-lactam

References

1. O'Donnell M, et al. J Pharmacol Exp Ther. 1994 Sep;270(3):1282-8.

2. O'Donnell M, et al. J Pharmacol Exp Ther. 1994 Sep;270(3):1289-94.

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Ro 25-1553 (Ro25-1553)

Biological Activity

Physicochemical Properties

References

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