Catalog No.: PC-22279Not For Human Use, Lab Use Only.
Ro 25-6981 maleate is a potent and selective antagonist of NMDA receptors containing NR2B subunits with IC50 of 3 nM for inhibition 3H-MK-801 binding to rat forebrain membranes.
Ro 25-6981 maleate is a potent and selective antagonist of NMDA receptors containing NR2B subunits with IC50 of 3 nM for inhibition 3H-MK-801 binding to rat forebrain membranes. Ro 25-6981 blocks NMDA receptor subtypes expressed in Xenopus oocytes with the subunit combinations NR1C & NR2B with IC50 of 9 nM, >5000-fold selectivity over NR1C & NR2A. Ro 25-6981 protected cultured cortical neurons against glutamate toxicity (16 h exposure to 300 microM glutamate) and combined oxygen and glucose deprivation (60 min followed by 20 h recovery) with IC50 values of 0.4 microM and 0.04 microM, respectively. Ro 25-6981 induced antinociception without motor dysfunction in vivo.
