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Chemical Structure : Ro 25-6981 maleate
CAS No.: 1312991-76-6
Catalog No.: PC-22279Not For Human Use, Lab Use Only.
Ro 25-6981 maleate is a potent and selective antagonist of NMDA receptors containing NR2B subunits with IC50 of 3 nM for inhibition 3H-MK-801 binding to rat forebrain membranes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
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| 100 mg | Get quote |
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Ro 25-6981 maleate is a potent and selective antagonist of NMDA receptors containing NR2B subunits with IC50 of 3 nM for inhibition 3H-MK-801 binding to rat forebrain membranes.
Ro 25-6981 blocks NMDA receptor subtypes expressed in Xenopus oocytes with the subunit combinations NR1C & NR2B with IC50 of 9 nM, >5000-fold selectivity over NR1C & NR2A.
Ro 25-6981 protected cultured cortical neurons against glutamate toxicity (16 h exposure to 300 microM glutamate) and combined oxygen and glucose deprivation (60 min followed by 20 h recovery) with IC50 values of 0.4 microM and 0.04 microM, respectively.
Ro 25-6981 induced antinociception without motor dysfunction in vivo.
| M.Wt | 455.55 | |
| Formula | C26H33NO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl)phenol maleate |
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1. Pinard E, et al. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2173-6.
2. Lynch DR, et al. Eur J Pharmacol. 2001 Mar 30;416(3):185-95.
3. Fischer G, et al. J Pharmacol Exp Ther. 1997 Dec;283(3):1285-92.
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