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Chemical Structure : Ro 28-1675
Catalog No.: PC-42677Not For Human Use, Lab Use Only.
Ro 28-1675 is a potent, allosteric activator of Glucokinase (GK) with SC1.5 of 0.24 uM.
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Ro 28-1675 is a potent, allosteric activator of Glucokinase (GK) with SC1.5 of 0.24 uM.
Ro 28-1675 augments both hepatic glucose metabolism and glucose-induced insulin secretion from isolated rodent pancreatic islets.
Ro 28-1675 lowers blood glucose levels and increases hepatic glucose uptake in rodent models of type 2 diabetes mellitus.
| M.Wt | 378.5089 | |
| Formula | C18H22N2O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Grimsby J, et al. Science. 2003 Jul 18;301(5631):370-3.
2. Haynes NE, et al. J Med Chem. 2010 May 13;53(9):3618-25.
3. McKerrecher D, et al. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2103-6.et al.
4. Assefa Z, et al. PLoS One. 2014 Jan 9;9(1):e85174.
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