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Ro 28-1675

Chemical Structure : Ro 28-1675

CAS No.: 300353-13-3

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Ro 28-1675 (Ro 028-1675, RO 0281675)

Catalog No.: PC-42677Not For Human Use, Lab Use Only.

Ro 28-1675 is a potent, allosteric activator of Glucokinase (GK) with SC1.5 of 0.24 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ro 28-1675 is a potent, allosteric activator of Glucokinase (GK) with SC1.5 of 0.24 uM.
Ro 28-1675 augments both hepatic glucose metabolism and glucose-induced insulin secretion from isolated rodent pancreatic islets.
Ro 28-1675 lowers blood glucose levels and increases hepatic glucose uptake in rodent models of type 2 diabetes mellitus.

Physicochemical Properties

M.Wt 378.5089
Formula C18H22N2O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzeneacetamide, α-(cyclopentylmethyl)-4-(methylsulfonyl)-N-2-thiazolyl-, (αR)-

References

1. Grimsby J, et al. Science. 2003 Jul 18;301(5631):370-3.

2. Haynes NE, et al. J Med Chem. 2010 May 13;53(9):3618-25.

3. McKerrecher D, et al. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2103-6.et al.

4. Assefa Z, et al. PLoS One. 2014 Jan 9;9(1):e85174.

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