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Ro 41-1049 hydrochloride

Chemical Structure : Ro 41-1049 hydrochloride

CAS No.: 127917-66-2

Ro 41-1049 hydrochloride (Ro41-4109 hydrochloride)

Catalog No.: PC-42039Not For Human Use, Lab Use Only.

Ro 41-1049 hydrochloride is a potent, selective, reversible, orally active monoamine oxidase A (MAO-A) inhibitor with Kd of 16.5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ro 41-1049 hydrochloride is a potent, selective, reversible, orally active monoamine oxidase A (MAO-A) inhibitor with Kd of 16.5 nM.
Ro 41-1049 produces a concentration-dependent increase of newly formed dopamine and reduces DOPAC formation in vitro (50-100 nM),

Physicochemical Properties

M.Wt 301.7675
Formula C12H13ClFN3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 32 mg/mL

Chemical Name/SMILES

4-Thiazolecarboxamide, N-(2-aminoethyl)-5-(3-fluorophenyl)-, hydrochloride (1:1)

References

1. Fernandes MH, et al. J Pharmacol Exp Ther. 1990 Dec;255(3):1309-13.

2. Saura J, et al. J Neurosci. 1992 May;12(5):1977-99.

3. Pestana M, et al. Br J Pharmacol. 1994 Dec;113(4):1269-74.

4. Cesura AM, et al. Mol Pharmacol. 1990 Mar;37(3):358-66.

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