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Ro5-4864

Chemical Structure : Ro5-4864

CAS No.: 14439-61-3

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Ro5-4864 (4'-Chlorodiazepam;Ro 5-4864;Ro 54864)

Catalog No.: PC-60195Not For Human Use, Lab Use Only.

Ro5-4864 is a potent, selective ligand for the mitochondrial translocator protein 18kDa (TSPO/PBR).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Ro5-4864 is a potent, selective ligand for the mitochondrial translocator protein 18kDa (TSPO/PBR).
    Ro5-4864 has proved to be neuroprotective and has become widely used for research into the role of the TSPO protein in neurotoxicity.
    Ro5-4864 shows analgesic, antidepressant, cardioprotective, and anti-cancer effects.

    Physicochemical Properties

    M.Wt 319.185
    Formula C16H12Cl2N2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one

    References

    1. File SE, et al. Psychopharmacology (Berl). 1984;82(3):199-202.

    2. Sakai M, et al. Eur J Pharmacol. 2006 Nov 21;550(1-3):8-14.

    3. Palzur E, et al. Neuroscience. 2016 Aug 4;329:162-70.

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