You are here:Home-Chemical Inhibitors & Agonists-GPCR-5-HT Receptor-Ro60-0175
Ro60-0175

Chemical Structure : Ro60-0175

CAS No.: 169675-08-5

Ro60-0175 (Ro 600175)

Catalog No.: PC-35018Not For Human Use, Lab Use Only.

Ro 60-0175 is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively.

Packing Price Stock Quantity
5 mg $288 In stock
10 mg $458 In stock
25 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ro60-0175 is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively.
Ro60-0175 induces hypolocomotion in rats at doses greater than 0.5 mg/kg s.c.
Ro60-0175 (0.3 and 1 mg/kg s.c.) simultaneously reduces both unpunished and punished lever pressing, a profile consistent with sedation, induces sedative-like responses via 5-HT(2C) receptor activation in vivo.

Physicochemical Properties

M.Wt 226.679
Formula C11H12ClFN2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-Indole-1-ethanamine, 6-chloro-5-fluoro-α-methyl-, (S)-

References

1. Damjanoska KJ, et al. J Pharmacol Exp Ther. 2003 Mar;304(3):1209-16.

2. Vickers SP, et al. Br J Pharmacol. 2000 Jul;130(6):1305-14.

3. Kennett G, et al. Eur J Pharmacol. 2000 Jan 10;387(2):197-204.

4. Jenck F, et al. Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: