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Chemical Structure : Ro60-0175
CAS No.: 169675-08-5
Catalog No.: PC-35018Not For Human Use, Lab Use Only.
Ro 60-0175 is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Ro60-0175 is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively.
Ro60-0175 induces hypolocomotion in rats at doses greater than 0.5 mg/kg s.c.
Ro60-0175 (0.3 and 1 mg/kg s.c.) simultaneously reduces both unpunished and punished lever pressing, a profile consistent with sedation, induces sedative-like responses via 5-HT(2C) receptor activation in vivo.
| M.Wt | 226.679 | |
| Formula | C11H12ClFN2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1H-Indole-1-ethanamine, 6-chloro-5-fluoro-α-methyl-, (S)- |
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1. Damjanoska KJ, et al. J Pharmacol Exp Ther. 2003 Mar;304(3):1209-16.
2. Vickers SP, et al. Br J Pharmacol. 2000 Jul;130(6):1305-14.
3. Kennett G, et al. Eur J Pharmacol. 2000 Jan 10;387(2):197-204.
4. Jenck F, et al. Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8.
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