Chemical Structure : Ro 61-8048
CAS No.:
199666-03-0
Ro 61-8048
(Ro-61-8048)
Catalog No. : PC-42997Not For Human Use, Lab Use Only.
Ro 61-8048 is a potent, orally active Kynurenine 3-monooxygenase (KMO) inhibitor with IC50 of 37 nM.
Packing Price Stock Quantity 10 mg $75 In stock 0 1 2 3 4 5 25 mg $145 In stock 0 1 2 3 4 5 100 mg $425 In stock 0 1 2 3 4 5 250 mg $725 In stock 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4299701
Biological Activity
Ro 61-8048 is a potent, orally active Kynurenine 3-monooxygenase (KMO) inhibitor with IC50 of 37 nM; effectively blocks rat and gerbil kynurenine 3-hydroxylase after oral administration, with ED50 of 3-5 uM/kg range in gerbil brain, reduce ischemic brain damage in models of focal or global brain ischemia; also improves dystonia in a genetic model of paroxysmal dyskinesia.
Physicochemical Properties
M.Wt
421.4475
Formula
C17H15N3O6S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 59 mg/mL
Chemical Name/SMILES
Benzenesulfonamide, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-
References
1. Röver S, et al. J Med Chem. 1997 Dec 19;40(26):4378-85.
2. Chiarugi A, et al. FEBS Lett. 1999 Jun 18;453(1-2):197-200.
3. Cozzi A, et al. J Cereb Blood Flow Metab. 1999 Jul;19(7):771-7.
4. Richter A, et al. Eur J Pharmacol. 2003 Sep 30;478(1):47-52.
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