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Chemical Structure : Ro 64-6198 hydrochloride
Catalog No.: PC-61543Not For Human Use, Lab Use Only.
Ro 64-6198 hydrochloride is a nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41.
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Ro 64-6198 hydrochloride is a nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41.
Ro 64-6198 displays >100-fold selectivity for ORL1 over other members of opioid receptor family.
Ro 64-6198 elicits dose-dependent anxiolytic-like effects in models of distinct types of anxiety states in rata, with no efficient anti-panic-like activity, absence of anticonvulsant properties, and lack of effects on motor performance and cognitive function at anxiolytic doses (0.3 to 3 mg/kg i.p.).
| M.Wt | 438.012 | |
| Formula | C26H32ClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chang SD, et al. ACS Chem Neurosci. 2015 Dec 16;6(12):1956-64.
2. Saccone PA, et al. J Pharmacol Exp Ther. 2016 Apr;357(1):17-23.
3. Jenck F, et al. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4938-43.
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