Catalog No.: PC-45194Not For Human Use, Lab Use Only.
Rofecoxib (MK-0996) is a potent, selective and orally active COX-2 inhibitor with IC50 of 26 nM for inhibition of the COX-2-dependent production of PGE2 in human osteosarcoma cells.
Rofecoxib (MK-0996) is a potent, selective and orally active COX-2 inhibitor with IC50 of 26 nM for inhibition of the COX-2-dependent production of PGE2 in human osteosarcoma cells.
Rofecoxib (MK-0996) displays 1,000-fold selectivity over COX-1 activity.
Rofecoxib (MK-0996) selectively inhibits LPS-induced, COX-2-derived PGE(2) synthesis after blood coagulation (IC50=0.53 uM).
Rofecoxib (MK-0996) exhibits anti-inflammation activity in osteoarthritis and rheumatoid arthritis rodent models.
