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Chemical Structure : Rofecoxib
CAS No.: 162011-90-7
Catalog No.: PC-45194Not For Human Use, Lab Use Only.
Rofecoxib (MK-0996) is a potent, selective and orally active COX-2 inhibitor with IC50 of 26 nM for inhibition of the COX-2-dependent production of PGE2 in human osteosarcoma cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $48 | In stock | |
| 250 mg | $78 | In stock | |
| 1 g | $148 | In stock | |
| 5 g | Get quote |
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Rofecoxib (MK-0996) is a potent, selective and orally active COX-2 inhibitor with IC50 of 26 nM for inhibition of the COX-2-dependent production of PGE2 in human osteosarcoma cells.
Rofecoxib (MK-0996) displays 1,000-fold selectivity over COX-1 activity.
Rofecoxib (MK-0996) selectively inhibits LPS-induced, COX-2-derived PGE(2) synthesis after blood coagulation (IC50=0.53 uM).
Rofecoxib (MK-0996) exhibits anti-inflammation activity in osteoarthritis and rheumatoid arthritis rodent models.
| M.Wt | 314.3557 | |
| Formula | C17H14O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2(5H)-Furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl- |
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1. Chan CC, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):551-60.
2. Ehrich EW, et al. Clin Pharmacol Ther. 1999 Mar;65(3):336-47.
3. Prasit P, et al. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1773-8.
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