Catalog No.: PC-45080Not For Human Use, Lab Use Only.
Rolipram (SB95952, ZK62711) is a potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
Rolipram (SB95952, ZK62711) is a potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
Rolipram increases phosphorylation of CREB in U937 cells in a dose-dependent fashion, dose-dependently inhibits the IFN-gamma-stimulated phosphorylation of p38 MAPK with IC50 of 290 nM.
Rolipram inhibits TNF production, attenuates carrageenan-induced paw inflammation in mice.
