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Rolipram

Chemical Structure : Rolipram

CAS No.: 61413-54-5

Rolipram (SB95952;ZK62711;(R,S)-Rolipram;SB 95952;ZK 62711;SB-95952;ZK-62711)

Catalog No.: PC-45080Not For Human Use, Lab Use Only.

A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

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50 mg $52.8 In stock
100 mg $78.4 In stock

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively; increases phosphorylation of CREB in U937 cells in a dose-dependent fashion, dose-dependently inhibits the IFN-gamma-stimulated phosphorylation of p38 MAPK with IC50 of 290 nM; inhibits TNF production, attenuates carrageenan-induced paw inflammation in mice.

Asthma

Phase 2 Clinical

Physicochemical Properties

M.Wt 275.3428
Formula C16H21NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 41 mg/mL

Chemical Name/SMILES

2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-

References

1. MacKenzie SJ, et al. Biochem J. 2000 Apr 15;347(Pt 2):571-8.

2. Korhonen R, et al. Br J Pharmacol. 2013 Aug;169(7):1525-36.

3. Shalaby AM, et al. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.

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