You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-Rolipram
Rolipram

Chemical Structure : Rolipram

CAS No.: 61413-54-5

Rolipram (SB95952, ZK62711, (R,S)-Rolipram, (±)-Rolipram)

Catalog No.: PC-45080Not For Human Use, Lab Use Only.

Rolipram (SB95952, ZK62711) is a potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

Packing Price Stock Quantity
50 mg $58 In stock
100 mg $88 In stock
250 mg $138 In stock
1 g Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Rolipram (SB95952, ZK62711) is a potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
Rolipram increases phosphorylation of CREB in U937 cells in a dose-dependent fashion, dose-dependently inhibits the IFN-gamma-stimulated phosphorylation of p38 MAPK with IC50 of 290 nM.
Rolipram inhibits TNF production, attenuates carrageenan-induced paw inflammation in mice.

Physicochemical Properties

M.Wt 275.3428
Formula C16H21NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 41 mg/mL

Chemical Name/SMILES

2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-

References

1. MacKenzie SJ, et al. Biochem J. 2000 Apr 15;347(Pt 2):571-8.

2. Korhonen R, et al. Br J Pharmacol. 2013 Aug;169(7):1525-36.

3. Shalaby AM, et al. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: