Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Rosuvastatin
CAS No.: 287714-41-4
Catalog No.: PC-45305Not For Human Use, Lab Use Only.
Rosuvastatin (ZD-4522) is a potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with IC50 of 11 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $88 | In stock | |
| 100 mg | $138 | In stock | |
| 500 mg | $258 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Rosuvastatin (ZD-4522) is a potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with IC50 of 11 nM.
Rosuvastatin (ZD-4522) potently inhibits cholesterol biosynthesis (IC50=1.12 nM) in rat isolated hepatocytes, 100 times more potent than pravastatin.
Rosuvastatin (ZD-4522) also exerts important anti-inflammatory effects via inhibition of endothelial cell adhesion molecule expression.
| M.Wt | 481.5376 | |
| Formula | C22H28FN3O6S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, (3R,5S,6E)- |
|
1. Watanabe M, et al. Bioorg Med Chem. 1997 Feb;5(2):437-44.
2. Kim YS, et al. J Cardiovasc Pharmacol. 2007 Jun;49(6):376-83.
3. Stalker TJ, et al. Br J Pharmacol. 2001 Jun;133(3):406-12.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
