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Rosuvastatin calcium

Chemical Structure : Rosuvastatin calcium

CAS No.: 147098-20-2

Rosuvastatin calcium (ZD-4522 calcium)

Catalog No.: PC-45304Not For Human Use, Lab Use Only.

Rosuvastatin (ZD-4522) calcium is a potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with IC50 of 11 nM.

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Biological Activity

Rosuvastatin (ZD-4522) calcium is a potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with IC50 of 11 nM.
Rosuvastatin potently inhibits cholesterol biosynthesis (IC50=1.12 nM) in rat isolated hepatocytes, 100 times more potent than pravastatin.
Rosuvastatin also exerts important anti-inflammatory effects via inhibition of endothelial cell adhesion molecule expression.

Physicochemical Properties

M.Wt 500.57
Formula C22H27Ca0.5FN3O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E)

References

1. Watanabe M, et al. Bioorg Med Chem. 1997 Feb;5(2):437-44.

2. Kim YS, et al. J Cardiovasc Pharmacol. 2007 Jun;49(6):376-83.

3. Stalker TJ, et al. Br J Pharmacol. 2001 Jun;133(3):406-12.

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