Roxyl-WL

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Chemical Structure : Roxyl-WL

Catalog No.: PC-35526Not For Human Use, Lab Use Only.

Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM.
Roxyl-WL displays excellent kinase spectrum selectivity with no activity out of the 337 protein kinases.
Roxyl-WL effectively augmentes the proliferation of T cells and reduces the number of regulatory T cell (Tregs).
Roxyl-WL significantly suppresses tumor growth and induces immune response in melanoma (B16F10) tumor-bearing mice orally.

Physicochemical Properties

M.Wt	370.372
Formula	C20H14N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,5-dibenzylbenzo[1,2-d:4,5-d']bis([1,2,3]triazole)-4,8(1H,5H)-dione

References

1. Xu G, et al. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1089-1094.

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Roxyl-WL

Biological Activity

Physicochemical Properties

References

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