Rucaparib phosphate |CAS:459868-92-9 Probechem Biochemicals

Chemical Structure : Rucaparib phosphate

CAS No.: 459868-92-9

Rucaparib phosphate (AG014699 phosphate;PF01367338 phosphate;AG 014699 phosphate;PF 01367338 phosphate;AG-014699 phosphate;PF-01367338 phosphate)

Catalog No.: PC-42679Not For Human Use, Lab Use Only.

Rucaparib (AG014699, PF 01367338) phosphate is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.

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Biological Activity

Rucaparib (AG014699, PF 01367338) phosphate is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.
Rucaparib inhibits PARP-1 activity by 97.1% at a concentration of 1 μM in permeabilised D283Med cells.
Rucaparib enhances the antitumor activity of temozolomide and indicates complete and sustained tumor regression in NB1691 and SHSY5Y xenografts.

Physicochemical Properties

M.Wt	421.3593
Formula	C19H21FN3O5P
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-, phosphate (1:1)

References

1. Thomas HD, et al. Mol Cancer Ther, 2007, 6(3), 945-956.

2. Daniel RA, et al. Clin Cancer Res, 2009, 15(4), 1241-1249.

3. Daniel RA, et al. Br J Cancer, 2010, 103(10), 1588-1596.

Rucaparib phosphate (AG014699 phosphate;PF01367338 phosphate;AG 014699 phosphate;PF 01367338 phosphate;AG-014699 phosphate;PF-01367338 phosphate)

Biological Activity

Physicochemical Properties

References

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