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Chemical Structure : Runcaciguat
CAS No.: 1402936-61-1
Catalog No.: PC-36097Not For Human Use, Lab Use Only.
Runcaciguat (BAY1101042) is a potent, selective soluble guanylyl cyclase (sGC) stimulator/activator with EC50 of 6 nM in cGMP formation assay with sGC-overexpressing CHO cell.
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|---|---|---|---|
| 5 mg | $238 | In stock | |
| 10 mg | $378 | In stock | |
| 25 mg | $588 | In stock | |
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| 100 mg | Get quote |
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Runcaciguat (BAY1101042) is a potent, selective soluble guanylyl cyclase (sGC) stimulator/activator with EC50 of 6 nM in cGMP formation assay with sGC-overexpressing CHO cell.
Runcaciguat (BAY1101042) binds and activates oxidized and heme-free sGC and thereby restores NO-sGC-cGMP signaling under oxidative stress.
Runcaciguat (BAY1101042) potently and selectively activates the heme-free form of sGC, resulting in the typical profile of an sGC activator in preclinical experiments, both in vitro and in vivo.
| M.Wt | 488.328 | |
| Formula | C23H22Cl2F3NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3S)-3-{4-chloro-3-[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanamido]phenyl}-3-cyclopropylpropanoic acid |
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1. PCT Int. Appl. (2018), WO 2018153899 A1 20180830.
2. PCT Int. Appl. (2012), WO 2012139888 A1 20121018.
3. Hahn MG, et al. J Med Chem. 2021 May 13;64(9):5323-5344.
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