Ruxuplam (SKY-0515) | HTT splicing modulator

Chemical Structure : Ruxuplam

Ruxuplam (SKY-0515, SKY0515)

Catalog No.: PC-27494Not For Human Use, Lab Use Only.

Ruxuplam (SKY-0515) is a small molecule splicing modulator to lower mHTT and post-meiotic segregation 1 (PMS1), shows potential for treatment of Huntington disease.

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Biological Activity

Ruxuplam (SKY-0515) is a small molecule splicing modulator to lower mHTT and post-meiotic segregation 1 (PMS1), shows potential for treatment of Huntington disease.

Physicochemical Properties

M.Wt	397.45
Formula	C21H24FN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Benzoxazolol, 6-[6-[[(1R,2R,3S,5S)-2-fluoro-9-azabicyclo[3.3.1]non-3-yl]methylamino]-3-pyridazinyl]-2-methyl-

References

1. Patent WO2025255218 A1 2025-12-11.

2. Patent WO2025006878 A1 2025-01-02.

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Ruxuplam (SKY-0515, SKY0515)

Biological Activity

Physicochemical Properties

References

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