Ruzasvir |Cas: 1613081-64-3 Buy Ruzasvir from ProbeChem, Global Biochemicals Supplier

Chemical Structure : Ruzasvir

Ruzasvir (MK-8408;MK 8408;MK8408)

Catalog No.: PC-60309Not For Human Use, Lab Use Only.

Ruzasvir (MK-8408) is a potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively.

Packing	Price	Stock	Quantity
25 mg		Get quote
100 mg		Get quote
250 mg		Get quote
1 g		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Ruzasvir (MK-8408) is a potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively.

Ruzasvir (MK-8408) inhibits HCV RNA replication with EC50s of 1 to 4 pM in Huh7 or Huh7.5 cells bearing replicons for HCV genotype 1 (GT1) to GT7.

Ruzasvir (MK-8408) is an HCV NS5A inhibitor with pan-genotypic profile.

Physicochemical Properties

M.Wt	947.09
Formula	C49H55FN10O7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Dimethyl N,N'-([(6S)-6-(2-cyclopropyl-1,3-thiazol-5-yl)-1-fluoro-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis{(1H-imidazole-4,2-diyl)[(2S)-pyrrolidine-2,1- diyl][(2S)-3-methyl-1-oxobutane-1,2-diyl]})dicarbamate

References

1. Tong L, et al. J Med Chem. 2017 Jan 12;60(1):290-306.

2. Wyles D, et al. Hepatology. 2017 Dec;66(6):1794-1804.

3. Lawitz E, et al. Lancet Gastroenterol Hepatol. 2017 Nov;2(11):814-823.

Ruzasvir (MK-8408;MK 8408;MK8408)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.