Chemical Structure : S-0636
CAS No.:
2374924-42-0
S-0636
(S0636)
Catalog No.: PC-26482Not For Human Use, Lab Use Only.
S-0636 is a potent, reversible inhibitor of zinc-dependent glutaminyl cyclase (PgQC) with Ki of 14 nM, selectively inhibits the bacterial virulence of P. gingivalis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
S-0636 is a potent, reversible inhibitor of zinc-dependent glutaminyl cyclase (PgQC) with Ki of 14 nM, selectively inhibits the bacterial virulence of P. gingivalis.
S-0636 has successfully reduced the intracellular PgQC activity by 50% at 8 μM and had no bactericidal effects.
S-0636 significantly decreased gingipain activity, impaired hemagglutination capacity, and reduced keratinocyte invasion by 76% at 62.5 μM against P. gingivalis.
S-0636 effectively attenuates P. gingivalis pathogenicity through selective virulence factor inhibition while preserving bacterial viability and oral microbiome integrity.
Physicochemical Properties
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M.Wt
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325.38
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Formula
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C16H19N7O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(2-(4-(((1H-imidazo[4,5-b]pyridin-6-yl)amino)methyl)phenoxy)ethyl)guanidine
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References
1. Taudte N, et al. Front Oral Health. 2026 Mar 13;7:1716188.
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