Chemical Structure : S-17092
CAS No.:
176797-26-5
S-17092
(S17092;S 17092)
Catalog No.: PC-70065Not For Human Use, Lab Use Only.
A highly potent, specific and cell permeant inhibitor of human proline endopeptidase (PE) with Ki of 1 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
A highly potent, specific and cell permeant inhibitor of human proline endopeptidase (PE) with Ki of 1 nM; shows no activity against a series of other peptidases including aminopeptidases B and M, dipeptidylaminopeptidase IV, endopeptidases, calpains and angiotensin-converting enzyme; significantly increases in SP- and alpha-MSH-like immunoreactivity in the frontal cortex and hypothalamus in rats (30mg/kg); shows cognition-enhancing properties in chronic low dose MPTP-treated monkeys.
Physicochemical Properties
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M.Wt
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384.53
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Formula
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C22H28N2O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropane-1-carbonyl)octahydro-1H-indol-2-yl)(thiazolidin-3-yl)methanone
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References
1. Barelli H, et al. Biochem Biophys Res Commun. 1999 Apr 21;257(3):657-61.
2. Bellemère G, et al. J Neurochem. 2003 Mar;84(5):919-29.
3. Schneider JS, et al. Neuropsychopharmacology. 2002 Feb;26(2):176-82.
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