Chemical Structure : S-18986
CAS No.:
175340-20-2
S-18986
(S18986)
Catalog No. : PC-61703Not For Human Use, Lab Use Only.
S-18986 is an orally bioavailable and BBB penetrant positive allosteric modulator of AMPA receptors.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6170301
Biological Activity
S-18986 is an orally bioavailable and BBB penetrant positive allosteric modulator of AMPA receptors.
Physicochemical Properties
M.Wt
224.28
Formula
C10H12N2O2S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2,3,3aS,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine, 5,5-dioxide
References
1. Lockhart B, et al. Eur J Pharmacol. 2000 Aug 4;401(2):145-53.
2. Lebrun C, et al. Eur J Pharmacol. 2000 Aug 4;401(2):205-12.
3. Rosi S, et al. Neurosci Lett. 2004 May 6;361(1-3):120-3.
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