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S-18986

Chemical Structure : S-18986

CAS No.: 175340-20-2

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S-18986 (S18986)

Catalog No.: PC-61703Not For Human Use, Lab Use Only.

S-18986 is an orally bioavailable and BBB penetrant positive allosteric modulator of AMPA receptors.

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25 mg $198 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

S-18986 is an orally bioavailable and BBB penetrant positive allosteric modulator of AMPA receptors.
S-18986 has nootropic and neuroprotective effects in animal studies, and induces both production of BDNF and AMPA-mediated release of noradrenaline and acetylcholine in the hippocampus and frontal cortex of the brain.

Physicochemical Properties

M.Wt 224.28
Formula C10H12N2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,3,3aS,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine, 5,5-dioxide

References

1. Lockhart B, et al. Eur J Pharmacol. 2000 Aug 4;401(2):145-53.

2. Lebrun C, et al. Eur J Pharmacol. 2000 Aug 4;401(2):205-12.

3. Rosi S, et al. Neurosci Lett. 2004 May 6;361(1-3):120-3.

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