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Chemical Structure : S-18986
CAS No.: 175340-20-2
Catalog No.: PC-61703Not For Human Use, Lab Use Only.
S-18986 is an orally bioavailable and BBB penetrant positive allosteric modulator of AMPA receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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S-18986 is an orally bioavailable and BBB penetrant positive allosteric modulator of AMPA receptors.
S-18986 has nootropic and neuroprotective effects in animal studies, and induces both production of BDNF and AMPA-mediated release of noradrenaline and acetylcholine in the hippocampus and frontal cortex of the brain.
| M.Wt | 224.28 | |
| Formula | C10H12N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2,3,3aS,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine, 5,5-dioxide |
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1. Lockhart B, et al. Eur J Pharmacol. 2000 Aug 4;401(2):145-53.
2. Lebrun C, et al. Eur J Pharmacol. 2000 Aug 4;401(2):205-12.
3. Rosi S, et al. Neurosci Lett. 2004 May 6;361(1-3):120-3.
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