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S-3448

Chemical Structure : S-3448

CAS No.: 254877-04-8

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S-3448 (S3448)

Catalog No.: PC-61609Not For Human Use, Lab Use Only.

S-3448 is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.68 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    S-3448 is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.68 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC.
    S-3448 increases cGMP levels in cultured rat aortic smooth muscle cells.
    S-3448 induces vasorelaxation of isolated endothelium-denuded rat aorta, porcine coronary arteries, and human corpus cavernosum with EC50 of 1-10 uM, elicits phosphorylation of the cGMP kinase substrate vasodilator-stimulated phosphoprotein at Ser239.

    Physicochemical Properties

    M.Wt 612.127
    Formula C25H26ClN3O7S3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-[(4-chlorophenyl)sulfonylamino]-4,5-dimethoxy-N-(4-thiomorpholin-4-ylsulfonylphenyl)benzamide

    References

    1. Schindler U, et al. Mol Pharmacol. 2006 Apr;69(4):1260-8.

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