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Chemical Structure : S. aureus antibiotic 1
Catalog No.: PC-21954Not For Human Use, Lab Use Only.
S. aureus antibiotic 1 is a novel antibiotic exhibiting antibiotic activity against Staphylococcus aureus (MIC=4 ug/mL, MRSA USA300), can overcome common resistance determinants and antibiotic tolerance in Gram-positive bacteria.
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S. aureus antibiotic 1 is a novel antibiotic exhibiting antibiotic activity against Staphylococcus aureus (MIC=4 ug/mL, MRSA USA300), can overcome common resistance determinants and antibiotic tolerance in Gram-positive bacteria.
S. aureus antibiotic 1 displays no cytotoxicity against HepG2 cells, HSkMCs, and IMR-90 cells.
S. aureus antibiotic 1 exhibits a structural scaffold distinct from those of known antibiotics.
S. aureus antibiotic 1 exhibits MIC ranges 2 to 16 ug/mL for 40 US Centers for Disease Control and Prevention (CDC) isolates of different bacterial species containing various resistance factors, including vancomycin, aminoglycoside/tetracycline and oxazolidinone resistance.
S. aureus antibiotic 1 is selective against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococci, evades substantial resistance, and reduces bacterial titres in mouse models of MRSA skin and systemic thigh infection.
| M.Wt | 374.60 | |
| Formula | C15H10Cl3NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Felix Wong, et al. Nature. 2024 Feb;626(7997):177-185.
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