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S. aureus antibiotic 2

Chemical Structure : S. aureus antibiotic 2

CAS No.: 667410-02-8

S. aureus antibiotic 2

Catalog No.: PC-21955Not For Human Use, Lab Use Only.

S. aureus antibiotic 2 is a novel antibiotic exhibiting antibiotic activity against Staphylococcus aureus (MIC=4 ug/mL, MRSA USA300), can overcome common resistance determinants and antibiotic tolerance in Gram-positive bacteria.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

S. aureus antibiotic 2 is a novel antibiotic exhibiting antibiotic activity against Staphylococcus aureus (MIC=4 ug/mL, MRSA USA300), can overcome common resistance determinants and antibiotic tolerance in Gram-positive bacteria.
S. aureus antibiotic 2 displays no cytotoxicity against HepG2 cells, HSkMCs, and IMR-90 cells.
S. aureus antibiotic 2 exhibits a structural scaffold distinct from those of known antibiotics.
S. aureus antibiotic 2 exhibits MIC ranges 2 to 16 ug/mL for 40 US Centers for Disease Control and Prevention (CDC) isolates of different bacterial species containing various resistance factors, including vancomycin, aminoglycoside/tetracycline and oxazolidinone resistance.
S. aureus antibiotic 2 is selective against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococci, evades substantial resistance, and reduces bacterial titres in mouse models of MRSA skin and systemic thigh infection.

Physicochemical Properties

M.Wt 419.05
Formula C15H10BrCl2NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-bromo-2-(2-(2,4-dichlorophenoxy)acetamido)benzoic acid

References

1. Felix Wong, et al. Nature. 2024 Feb;626(7997):177-185.

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