Catalog No.: PC-49717Not For Human Use, Lab Use Only.
S07662 is a human constitutive androstane receptor (CAR, NR1I3) inverse agonist with IC50 of 0.7 uM, strongly inhibits human CAR activity via recruitment of NR corepressors and to attenuate inducer-elicited CYP2B6 expression in human primary hepatocytes.
S07662 is a human constitutive androstane receptor (CAR, NR1I3) inverse agonist with IC50 of 0.7 uM, strongly inhibits human CAR activity via recruitment of NR corepressors and to attenuate inducer-elicited CYP2B6 expression in human primary hepatocytes.
S07662 attenuates the phenytoin- and CITCO-induced expression of CYP2B6 mRNA in human primary hepatocytes.
S07662 is a chemical tool to study the biological functions of human CAR and also as a starting point for the development of new drugs for various conditions involving the receptor.
