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Chemical Structure : S07662
Catalog No.: PC-49717Not For Human Use, Lab Use Only.
S07662 is a human constitutive androstane receptor (CAR, NR1I3) inverse agonist with IC50 of 0.7 uM, strongly inhibits human CAR activity via recruitment of NR corepressors and to attenuate inducer-elicited CYP2B6 expression in human primary hepatocytes.
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S07662 is a human constitutive androstane receptor (CAR, NR1I3) inverse agonist with IC50 of 0.7 uM, strongly inhibits human CAR activity via recruitment of NR corepressors and to attenuate inducer-elicited CYP2B6 expression in human primary hepatocytes.
S07662 attenuates the phenytoin- and CITCO-induced expression of CYP2B6 mRNA in human primary hepatocytes.
S07662 is a chemical tool to study the biological functions of human CAR and also as a starting point for the development of new drugs for various conditions involving the receptor.
| M.Wt | 300.38 | |
| Formula | C16H16N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Küblbeck J, et al. Mol Pharm. 2011 Dec 5;8(6):2424-33.
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