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S1P1 Agonist 8

Chemical Structure : S1P1 Agonist 8

CAS No.: 1324003-64-6

S1P1 Agonist 8 (S1P1 agonist III )

Catalog No.: PC-43245Not For Human Use, Lab Use Only.

S1P1 Agonist 8 is a potent, selective, orally bioavailable S1P1 receptor agonist with EC50 of 35 nM (S1P1 internalization), >100-fold selectivity over against receptor subtypes S1P2-5.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

S1P1 Agonist 8 is a potent, selective, orally bioavailable S1P1 receptor agonist with EC50 of 35 nM (S1P1 internalization), >100-fold selectivity over against receptor subtypes S1P2-5。
S1P1 Agonist 8 induces dose-dependent reduction in lymphocyte count in rats.

Physicochemical Properties

M.Wt 415.3652
Formula C21H16F3N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-Pyridinecarboxamide, 4-methoxy-N-[[[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]amino]carbonyl]-

References

1. Harrington PE, et al. ACS Med Chem Lett. 2011 Nov 23;3(1):74-8.

2. Pennington LD, et al. ACS Med Chem Lett. 2011 Jul 29;2(10):752-7.

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