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S1RA hydrochloride

Chemical Structure : S1RA hydrochloride

CAS No.: 1265917-14-3

S1RA hydrochloride (E-52862 hydrochloride)

Catalog No.: PC-45418Not For Human Use, Lab Use Only.

S1RA hydrochloride (E52862) is a potent and selective sigma-1 receptor (S1R) antagonist with Ki of 17 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

S1RA hydrochloride (E52862) is a potent and selective sigma-1 receptor (S1R) antagonist with Ki of 17 nM.
S1RA (E52862)  shows excellent selectivity over sigma-2 receptor (Ki>1 uM).
S1RA (E52862)  shows high activity in the mouse capsaicin model of neurogenic pain, exerts dose-dependent antinociceptive effects in several neuropathic pain models.

Physicochemical Properties

M.Wt 373.8765
Formula C20H24ClN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 57 mg/mL

Chemical Name/SMILES

Morpholine, 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-, hydrochloride (1:1)

References

1. Díaz JL, et al. J Med Chem. 2012 Oct 11;55(19):8211-24.

2. Romero L, et al. Br J Pharmacol. 2012 Aug;166(8):2289-306.

3. Nieto FR, et al. J Pain. 2012 Nov;13(11):1107-21.

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