Chemical Structure : S21-1011
CAS No.:
2671859-87-1
S21-1011
Catalog No.: PC-22297Not For Human Use, Lab Use Only.
S21-1011 is a potent, selective, BBB-penetrant butyrylcholinesterase (BChE) inhibitor with IC50 of 59 nM and 162 nM for eqBChE and hBChE, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
S21-1011 is a potent, selective, BBB-penetrant butyrylcholinesterase (BChE) inhibitor with IC50 of 59 nM and 162 nM for eqBChE and hBChE, respectively.
S21-1011 displays 508-fold and 190-fold selectivity for eqBChE and hBChE over electrophorus electricus AChE (eeAChE), respectively.
S21-1011 shows europrotective effects against H2O2-induced neuronal damages on PC12 cells.
S21-1011 plays a neuroprotective and anti-oxidative character to protect cells from damages triggered by Aβ, LPS and H2O2.
S21-1011 functions as a neuroprotective role via activating Nrf2 pathway and resisting inflammation injuries.
S21-1011 alleviates cognitive impairment caused by Aβ deposits in various AD model mice.
Physicochemical Properties
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M.Wt
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464.61
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Formula
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C30H32N4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-(4-benzylpiperazin-1-yl)quinolin-3-yl)-4-propylbenzamide
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References
1. Ying Chen, et al. Eur J Med Chem. 2024 Apr 30:272:116463.
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