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S 38093

Chemical Structure : S 38093

CAS No.: 1222097-72-4

S 38093 (S-38093, S38093)

Catalog No.: PC-60377Not For Human Use, Lab Use Only.

S 38093 is a brain-penetrant H3 receptor antagonist/inverse agonist that shows procognitive properties in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

S 38093 is a brain-penetrant H3 receptor antagonist/inverse agonist that shows procognitive properties in vivo.
S 38093 induces synergistic memory-enhancing effect in mice combined with Donepezil.
S 38093 induces a reversal of age-dependent effects on hippocampal BDNF-IX, BDNF-IV and BDNF-I transcripts and increases vascular endothelial growth factor (VEGF) expression, increases adult hippocampal neurogenesis in vivo.

Physicochemical Properties

M.Wt 324.85
Formula C17H25ClN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(3-(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)propoxy)benzamide hydrochloride

References

1. Panayi F, et al. Eur J Pharmacol. 2017 May 15;803:1-10.

2. Sors A, et al. Eur J Pharmacol. 2017 May 15;803:11-23.

3. Guilloux JP, et al. Sci Rep. 2017 Feb 20;7:42946.

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